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Figure 3: Comparisons of dose-volume parameters of the planning target volume between the clinical plans (CLPs) and knowledge-based plans (KBPs) using the TrueBeam and Halcyon in closed- and open-loop validations (KBPclosed-TB, KBPclosed-Hal, KBPopen-TB, and KBPopen-Hal, respectively). Central line of each box: median line; lower line: first quartile; upper line: third quartile. Whisker ranges do not contain outliers, which are plotted as individual points. N.S.; not significant, *P < 0.05, **P < 0.01, ***P < 0.001

Figure 3: Comparisons of dose-volume parameters of the planning target volume between the clinical plans (CLPs) and knowledge-based plans (KBPs) using the TrueBeam and Halcyon in closed- and open-loop validations (KBP<sub>closed</sub>-TB, KBP<sub>closed</sub>-Hal, KBP<sub>open</sub>-TB, and KBP<sub>open</sub>-Hal, respectively). Central line of each box: median line; lower line: first quartile; upper line: third quartile. Whisker ranges do not contain outliers, which are plotted as individual points. N.S.; not significant, *<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001