Journal of Medical Physics

Year
: 1998  |  Volume : 23  |  Issue : 1  |  Page : 20--24

Dependence Of Therapeutic Gain Factor On Stage Of Oral Cancer


J Velmurugan1, S.S Supe2, G.N.S Prasad3, J.G.R Solomon4, K Koteshwer Rao5 
1 
2 
3 
4 
5 

Correspondence Address:
J Velmurugan


To achieve therapeutic gain, unconventional dose per fraction has been employed in radiotherapy, in addition to the conventional dose per fraction of 2 Gy. Dose Fractionation Factor (DFF) and Therapeutic Gain Factor VGF) have been utilised to test the efficiency of such unconventional fractionation schedules. In this study, isoeffective dose for 100% tumour regression and mucossal and skin reactions were estimated. CUE, TDF and ERD values for tumour and normal tissue reactions were evaluated. DEF and TGF values have been determined on the basis of dose, CRE, TDF and ERD, in order to understand the influence of these bioeffect models and stage of cancer on TGF associated with differing fractionation schedules. There was a noticeable difference in TGF values determined on the basis of four criteria, which is in agreement with radiobiological phenomenon; that tissues with different alp values differ in their responsiveness.


How to cite this article:
Velmurugan J, Supe S, Prasad G, Solomon J, Koteshwer Rao K. Dependence Of Therapeutic Gain Factor On Stage Of Oral Cancer.J Med Phys 1998;23:20-24


How to cite this URL:
Velmurugan J, Supe S, Prasad G, Solomon J, Koteshwer Rao K. Dependence Of Therapeutic Gain Factor On Stage Of Oral Cancer. J Med Phys [serial online] 1998 [cited 2021 Apr 20 ];23:20-24
Available from: https://www.jmp.org.in/article.asp?issn=0971-6203;year=1998;volume=23;issue=1;spage=20;epage=24;aulast=Velmurugan;type=0