TY - JOUR
A1 - Oinam, Arun
A1 - Singh, Lakhwant
A1 - Shukla, Arvind
A1 - Ghoshal, Sushmita
A1 - Kapoor, Rakesh
A1 - Sharma, Suresh
T1 - Dose volume histogram analysis and comparison of different radiobiological models using in-house developed software
Y1 - 2011/10/1
JF - Journal of Medical Physics
JO - J Med Phys
SP - 220
EP - 229
VL - 36
IS - 4
UR - https://www.jmp.org.in/article.asp?issn=0971-6203;year=2011;volume=36;issue=4;spage=220;epage=229;aulast=Oinam
DO - 10.4103/0971-6203.89971
N2 - The purpose of this study is to compare Lyman-Kutcher-Burman (LKB) model versus Niemierko model for normal tissue complication probability (NTCP) calculation and Niemierko model versus Poisson-based model for tumor control probability (TCP) calculation in the ranking of different treatment plans for a patient undergoing radiotherapy. The standard normal tissue tolerance data were used to test the NTCP models. LKB model can reproduce the same complication probability data of normal tissue response on radiation, whereas Niemierko model cannot reproduce the same complication probability. Both Poisson-based and Niemierko models equally reproduce the same standard TCP data in testing of TCP. In case of clinical data generated from treatment planning system, NTCP calculated using LKB model was found to be different from that calculated using Niemierko model. When the fractionation effect was considered in LKB model, the calculated values of NTCPs were different but comparable with those of Niemierko model. In case of TCP calculation using these models, Poisson-based model calculated marginally higher control probability as compared to Niemierko model.
ER -