Journal of Medical Physics
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Year : 1998  |  Volume : 23  |  Issue : 1  |  Page : 25-30

Many Component Model For Fractionated Radiotherapy And Proliferation Kinetics In Different Kinds Of Tissues



Correspondence Address:
T.S Kehwar


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Source of Support: None, Conflict of Interest: None


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This study is aimed to provide an appropriate extension of recently proposed many component (MC) model to address the issue of proliferation which occurs during and after irradiation in different kinds of tissues and tumours. The proliferation is an essential and important feature of early-reacting tissues and tumours which alters the treatment recommendations. . The original MC model is unable to explain the effect of proliferation in the absence of a correction factor. Therefore, a proliferation correction factor, in terms of a time factor, is incorporated into the expression of survival fraction of MC model using an assumption that the proliferating cells grow exponentially and hence there will be an exponential increment in the survival fraction during the interval period between successive fractions. The final expression of the survival fraction is S - exp [-aDexp (bd) + (0.693 / Tp) (T-Td)], where notations are having their usual meanings. The expressions of effect, E - 1 -exp [-aDexp (bd) + (0.693 / Tp) (T-Td)] and biologically responsive dose, BRD - Dexp (bd)- (0.6931a Tp) (T-Td), are very important equations of MC model. The BRD equation is applied to compare some of the currently used radiotherapy schedules. The results of the study indicate that for fast proliferating tumours, the Manchester schedules would be more effective to get good response and tumor control among the analyzed schedules but would lead to more early and late tissue damage.


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