Journal of Medical Physics
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Year : 1994  |  Volume : 19  |  Issue : 2  |  Page : 59-63

TDF And ERD AS Potential Tools In The Combined External And Intracavitary Radiotherapy Treatments Of Carcinoma Of The Uterine Cervix

Correspondence Address:
Sanjay S Supe

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Source of Support: None, Conflict of Interest: None

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A retrospective analysis of 291 patients with cancer of the uterine cervix treated with a combination of external and intracavitary radiotherapy was carried out. Patients were treated with external radiotherapy dose of 45 Gy in 20 fractions, 5 fractions per week or 42 Gy in 14 fractions, 3 fractions per week. For brachytherapy the total dose was 24 to 32 Gy at a dose rate of 1.4 to 2.2 Gy per hour. Treatment results in terms of response, survival, recurrence and complication were correlated with Time Dose Fractionation (TDF) and Extrapolated Response Dose (ERD) values for point A(TDFTA and ERDTA) and for rectum (TDFTr and ERDTr) respectively. TDFTA and ERDTA values did not correlate with response, recurrence and survival rates (p value> 0.05). Correlations of TDFTA and ERDTA with overall complication rate (p value < 0.05) and with rectal complication rate (p value c 0.025) were excellent. Lack of correlation was observed between TDFTr and ERDTr for overall complication rate (p value> 0.1) and rectal complication rate (p value> 0.1). In the same group of patients, both models that have been used in this study showed statistically significant correlation in the assessment of overall and rectal complication rate. In order to limit Grade II and Ill rectal complications to acceptable level, in combined external and intracavitary treatments, TDFTA and ERDTA values of less than 151 and 93 respectively are suggested.

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