Journal of Medical Physics
 Home | Search | Ahead of print | Current Issue | Archives | Instructions | Subscription | Login  The official journal of AMPI, IOMP and AFOMP      
 Users online: 313  Home  EMail this page Print this page Decrease font size Default font size Increase font size 
Year : 1994  |  Volume : 19  |  Issue : 2  |  Page : 59-63

TDF And ERD AS Potential Tools In The Combined External And Intracavitary Radiotherapy Treatments Of Carcinoma Of The Uterine Cervix



Correspondence Address:
Sanjay S Supe


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

A retrospective analysis of 291 patients with cancer of the uterine cervix treated with a combination of external and intracavitary radiotherapy was carried out. Patients were treated with external radiotherapy dose of 45 Gy in 20 fractions, 5 fractions per week or 42 Gy in 14 fractions, 3 fractions per week. For brachytherapy the total dose was 24 to 32 Gy at a dose rate of 1.4 to 2.2 Gy per hour. Treatment results in terms of response, survival, recurrence and complication were correlated with Time Dose Fractionation (TDF) and Extrapolated Response Dose (ERD) values for point A(TDFTA and ERDTA) and for rectum (TDFTr and ERDTr) respectively. TDFTA and ERDTA values did not correlate with response, recurrence and survival rates (p value> 0.05). Correlations of TDFTA and ERDTA with overall complication rate (p value < 0.05) and with rectal complication rate (p value c 0.025) were excellent. Lack of correlation was observed between TDFTr and ERDTr for overall complication rate (p value> 0.1) and rectal complication rate (p value> 0.1). In the same group of patients, both models that have been used in this study showed statistically significant correlation in the assessment of overall and rectal complication rate. In order to limit Grade II and Ill rectal complications to acceptable level, in combined external and intracavitary treatments, TDFTA and ERDTA values of less than 151 and 93 respectively are suggested.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed441    
    Printed28    
    Emailed0    
    PDF Downloaded56    
    Comments [Add]    

Recommend this journal