Journal of Medical Physics
ORIGINAL ARTICLE
Year
: 2011  |  Volume : 36  |  Issue : 3  |  Page : 159--170

Comparison of no-prior and soft-prior regularization in biomedical microwave imaging


Amir H Golnabi, Paul M Meaney, Shireen D Geimer, Keith D Paulsen 
 Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA

Correspondence Address:
Amir H Golnabi
8000 Cummings Hall, Thayer School of Engineering, Hanover NH 03755-8000
USA

Microwave imaging for medical applications is attractive because the range of dielectric properties of different soft tissues can be substantial. Breast cancer detection and monitoring of treatment response are areas where this technology could be important because of the contrast between normal and malignant tissue. Unfortunately, the technique is unable to achieve the high spatial resolution at depth in tissue which is available from other conventional modalities such as x-ray computed tomography (CT) or magnetic resonance imaging (MRI). We have incorporated a soft-prior regularization strategy within our microwave reconstruction algorithm and compared it with the images obtained with traditional no-prior (Levenberg-Marquardt) regularization. Initial simulation and phantom results show a significant improvement of the recovered electrical properties. Specifically, errors in the microwave property estimates were improved by as much as 95%. The effects of a false-inclusion region were also evaluated and the results show that a small residual property bias of 6% in permittivity and 15% in conductivity can occur that does not otherwise degrade the property recovery accuracy of inclusions that actually exist. The work sets the stage for integrating microwave imaging with MR for improved resolution and functional imaging of the breast in the future.


How to cite this article:
Golnabi AH, Meaney PM, Geimer SD, Paulsen KD. Comparison of no-prior and soft-prior regularization in biomedical microwave imaging.J Med Phys 2011;36:159-170


How to cite this URL:
Golnabi AH, Meaney PM, Geimer SD, Paulsen KD. Comparison of no-prior and soft-prior regularization in biomedical microwave imaging. J Med Phys [serial online] 2011 [cited 2019 Nov 14 ];36:159-170
Available from: http://www.jmp.org.in/article.asp?issn=0971-6203;year=2011;volume=36;issue=3;spage=159;epage=170;aulast=Golnabi;type=0