Year : 2008 | Volume
: 33 | Issue : 3 | Page : 114--118
Dosimetric evaluation of 120-leaf multileaf collimator in a Varian linear accelerator with 6-MV and 18-MV photon beams
R Mohan1, K Jayesh1, RC Joshi1, Maha Al-idrisi1, P Narayanamurthy2, Saroj Kumar Das Majumdar1,
1 Department of Radiation Oncology, King Fahad Specialist Hospital, Ministry of Health, Dammam, Saudi Arabia
2 Department of Physics, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India
Department of Radiation Oncology, King Fahad Specialist Hospital, P.O. Box No.15215, Dammam, PIN-31444
In this study the dosimetric characteristics of 120-leaf multileaf collimators (MLCs) were evaluated for 6-MV and 18-MV photon beams. The dose rate, percentage depth dose, surface dose, dose in the build-up region, beam profile, flatness, symmetry, and penumbra width were measured using three field-defining methods: (i) «SQ»Jaw only«SQ», (ii) «SQ»MLC only«SQ», and (iii) «SQ»MLC+Jaw«SQ». Analysis of dose rate shows that the dose rate for «SQ»MLC only«SQ» field was higher than that for «SQ»Jaw only«SQ»«SQ» and «SQ»MLC+Jaw«SQ» fields in both the energies. The «SQ»percentage of difference«SQ» of dose rates between «SQ»MLC only«SQ» and «SQ»MLC+Jaw«SQ» was (0.9% to 4.4%) and (1.14% to 7%) for 6 MV and 18 MV respectively. The surface dose and dose in the build-up region were more pronounced for «SQ»MLC only«SQ» fields for both energies, and no significant difference was found in percentage depth dose beyond dmax for both energies. Beam profiles show that flatness and symmetry for both the energies were less than the 3%. The penumbra width for «SQ»MLC only«SQ» field was more than that for the other two field-defining methods by (1 to 2 mm) and (0.8 to 1.3 mm) for 6-MV and 18-MV photon beams respectively. Analysis of «SQ»width of 50% dose level«SQ» of the beam profiles at dmax to reflect the field size shows 1 to 2 mm more for 6-MV photons and 2.2 to 2.4 mm morefor 18-MV photons for «SQ»MLC only«SQ» fields. The results of this study suggest that the characteristics of 120-leaf MLC system with 6 MV and 18 MV are same in all aspects except the surface dose, penumbra, dose in the build-up region, and width of 50% dose levels.
|How to cite this article:|
Mohan R, Jayesh K, Joshi R C, Al-idrisi M, Narayanamurthy P, Majumdar SD. Dosimetric evaluation of 120-leaf multileaf collimator in a Varian linear accelerator with 6-MV and 18-MV photon beams.J Med Phys 2008;33:114-118
|How to cite this URL:|
Mohan R, Jayesh K, Joshi R C, Al-idrisi M, Narayanamurthy P, Majumdar SD. Dosimetric evaluation of 120-leaf multileaf collimator in a Varian linear accelerator with 6-MV and 18-MV photon beams. J Med Phys [serial online] 2008 [cited 2020 Feb 26 ];33:114-118
Available from: http://www.jmp.org.in/text.asp?2008/33/3/114/42757
The three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), and image-guided radiotherapy (IGRT) are the most advanced techniques in radiotherapy, which use irregular fields-using multileaf collimators in a linear accelerator. The accuracy of these techniques depends on dosimetric characteristics of the multileaf collimators. There is an option for optimizing the jaws to the irregular MLC field to reduce the scattered radiation and intra- and inter-leaf radiation leakage beyond the field. In this study, 120-leaf MLC system has been taken to compare and differentiate their characteristics with 6-MV and 18-MV photon beams.
The MLC system in Varian linear accelerator is used as a tertiary collimator, that is, below the collimator jaws. When both 'X' and 'Y' jaws are optimized to the MLC field, the surface dose decreases by reducing the intra- and inter-leaf leakage radiation.  The dosimetric characteristics include dose rates, percentage depth doses, surface dose, dose in the build-up region, penumbra, and width of 50% dose levels.
Materials and Methods
Varian 2300CD CLINAC linear accelerator with 6-MV and 18-MV photon beams and 120-leaf multileaf collimator. Eclipse treatment planning system, PTWMP3 3D water phantom with 0.125-cc field and reference chambers, 0.6-cc farmer chamber, and PTW solid water (slab) phantom.
A. 120-leaf MLC system
The Varian 120-leaf MLC system consists of an MLC head assembly and control system. The MLC system is attached to the head of the CLINAC 2300CD as a tertiary collimator consisting a pair of 60 opposed leaves. These leaves are mounted in two leaf banks below 'X' jaws. The leaf width at the isocenter for each of the central 80 leaves is 0.5 cm; and for all others, it is 1.0 cm.
B. Measurement of dosimetric characteristics
Measurements were made in water using PTW MP3 water phantom using the following methods:
MLC field with jaws optimized (MLC+Jaw) - optimization methodMLC field with jaws parked at 35×35 cm (MLC only) - non-optimization methodJaw field with X1, X2, Y1, and Y2 jaws (Jaw only)
C. Dose rate (DR)
The dose rate was measured in a PTW solid water (slab) phantom using a 0.6-cc PTW (PTW-Freiburg) waterproof ion chamber and a PTW UNIDOS digital electrometer. The solid phantom is tissue equivalent with a density of 1.045 g/cc; its dimensions are 30×30×30 cm (width×length×depth). It has a slot to position the 0.6-cc chamber. All measurements were made in source-to-surface distence(SSD) setup of 100 cm for field sizes 5×5 cm², 10×10 cm², 15×15 cm², 20×20 cm², and 30×30 cm² using IAEA TRS-398 absolute dose calculation protocol, for all the above-mentioned fields for 6-MV and 18-MV photon beams at a reference of depths 5 cm and 10 cm respectively.
D. Percentage depth dose and beam profile
The central axis percentage depth dose (PDD) and beam profile were measured using PTW MP3 3D radiation field analyzer system controlled by Mephysto computer software. The RFA consists of a cubic water tank with inner dimensions 60×50×40.75 cm (width×length×depth). The drive mechanism of the scanning system has a positional accuracy of ±0.5 mm and reproducibility of ±0.1 mm. Semi flex cylindrical chambers, 0.125 cc, were used . The measuring chamber was positioned perpendicular to the radiation beam and parallel to the water surface. A reference detector was placed in one quadrant corner of the radiation field so that it does not interfere with the reading of the field detector. The PDD and beam profile were measured for source-to-surface (SSD) = 100 cm, for the square fields 5×5 cm², 10×10 cm², 20×20 cm² and 30×30 cm², using all the three field-defining methods as described in section B.
Results and Discussion
Dose rate (DR) in medium was measured as described in section C, at a reference depth of 5 cm for 6-MV and 10 cm for 18-MV photon beams. The increases in the DR as shown in [Figure 1] and [Figure 2] were more pronounced for the fields defined by 'MLC only' and had higher values compared to those for the fields defined by 'Jaw only' and/or 'MLC+Jaw'. The range of 'percentage of difference' between the 'MLC only' field and 'MLC+Jaw' field was (0.9% to 4.40%) and (1.14% to 7%) for 6-MV and 18-MV photons respectively. It was found that there was no significant difference between the dose rates of 'MLC+Jaw' and 'Jaw only'' fields in both the energies. The increase in dose rate due to MLC+Jaw fields may be due to increase in head scatter with MLC. ,,, The leaf setting strategy and effect of leaf width on physical dose distributions were discussed by Yu et al. and Fiveash et al. respectively. ,
[Table 1] and [Table 2] show the comparison of PDD parameters for all the fields using the three field-defining methods for 6-MV and 18-MV photon beams. The PDD data was measured at SSD = 100 cm, for the depth ranging from 0 to 30 cm for all the fields. The measurement are performed with the three field-defining methods (i) Jaw only (MLC in park position), (ii) MLC only - (fixed jaws opening at 35×35 cm), and (iii) MLC+Jaw (jaw optimized to MLC irregular 'MLC+Jaw' Fields.). From [Table 1] and [Table 2], it is clear that the surface dose (S-0) for 6 MV and 18 MV was higher for field sizes defined by 'MLC only' than that for field sizes defined by 'Jaw only' and 'MLC+Jaw'. The 'percentage of difference' of surface dose between 'MLC only' and 'MLC+Jaw' fields was (2% to 3%) and (3.5% to 5%) for 6-MV and 18-MV photons respectively. It was found that the dose in the build-up region was higher for the 'MLC only' field than that for the other two field-defining methods in both energies. It was found that the position of 'depth of dose maximum' (dmax) shifted more towards the surface for 18 MV compared to 6 MV, with increase in the field size. No significant difference in the PDD was observed beyond the dmax, that is, depth between dmax to 30 cm, for both the energies.  The difference in the 'depth of 80% dose' was within 0.5 to 1.5 mm for 6-MV and 1 to 4 mm for 18-MV photon beams for all the field defining methods. There were no significant variations when comparing the quality index (QI) with the three field-defining methods, for both the energies. The 120-leaf MLC system, which has a 5 mm leaf width, improves the dose coverage to the tumor volume and is useful in organ avoidance in head and neck tumors.  This will produce an ideal DVH curve for a tumor volume which gives uniform dose distribution; and at the same time, DVH of critical organs will show minimum dose contribution. In studies, ,,,,,, various dosimetric characteristics of multileaf collimators are measured and analyzed. The increase in the surface dose and dose rate will definitely not have any effect on the dose to the tumor, and there shall be no consequence on the clinical approach and outcome.
The beam profiles were measured using 120-leaf MLC system, for the square field sizes 5×5 cm², 10×10 cm², 20×20 cm², and 30×30 cm² at dmax and 10 cm in the cross-plane orientation for the three field-defining methods mentioned in section D. The flatness and symmetry of the beam profiles were determined for the fields defined above; it was found that the flatness and symmetry were within 3% for both energies. The 'width of 50% dose level' was measured and analyzed; it was observed that the width of the 'MLC only' field was higher by 2 to 4 mm for 6-MV and 1 to 2.8 mm for 18-MV photon when compared with 'Jaw only' and/or 'MLC+ Jaw' fields. [Table 3] and [Table 4] show the comparison of the 'widths of the 50% dose level' in the three field-defining methods for 6 MV and 18 MV respectively. The penumbra (80% to 20%) was measured at depth dmax and 10 cm. Penumbra of 'MLC only' field was more than that of 'Jaw only' and 'MLC+ Jaw' by 1.5 to 3 mm for 6-MV and 2 to 3 mm for 18-MV photon beam. [Figure 3],[Figure 4],and [Figure 5] show the penumbra at depth dmax for 6 MV and 18 MV respectively, and [Figure 4],[Figure 5] and [Figure 6] show the penumbra at depth 10 cm for 6 MV and 18 MV respectively. A study  compared the penumbra width (80% to 20%) of 10 mm leaf of three manufacturers and found that the smallest was in the Varian MLC system.
The dosimetric characteristics of the Varian 120-leaf MLC system were measured, compared, and analyzed using 6-MV and 18-MV photon beams. It was found that its characteristics were quite similar to those of the standard collimator (jaws) system except for the dose rate, surface dose, dose in the build-up region, width of 50% dose level and penumbra. Dose rate for 6-MV and 18-MV photon beams was higher for 'MLC only' field than that for the other two field-defining methods. The PDD comparison shows that the surface dose and dose in the build-up region were more for 'MLC only' fields. Beam profile analysis shows that the flatness and symmetry for both the systems were within 3%; the 'width of 50% dose level' and penumbra were slightly higher for 'MLC only' fields in both energies. The 120-leaf MLC system with 5 mm leaf width showed improved dose coverage to the tumor volume and was found to be useful in organ avoidance in head and neck tumors. The results of this study suggest that standard collimator jaws should be optimized to the irregular MLC field (i.e., MLC+Jaw) to minimize the surface dose, dose rate, penumbra, and dose in the build-up region.
|1||Kehwar TS, Bhardwaj AK, Chakarvarti SK. Evaluation of dosimetric effect of leaf position in a radiation field of an 80-leaf multileaf collimator fitted to the LINAC head as a tertiary collimator. J Appl Clin Med Physics 2006;7:43-54.|
|2||Zhu TC, Bjδrngard BE, Xiao Y, Bieda M. Output ratio in air for MLC shaped irregular fields. Med Phys 2004;31:2480-90.|
|3||Boyer AL, Ochran TG, Nyerick CE, Waldron TJ, Huntzinger CJ. Clinical dosimetry for implementation of a multileaf collimator. Med Phys 1992;19:1255-61.|
|4||Chow JC, Wettlaufer B, Jiang R. Dosimetric effects on the penumbra region of irregular multi-leaf collimated fields. Phys Med Biol 2006;51:N31-8.|
|5||Ma L, Yu C, Sarfaraz M. A dosimetric leaf-setting strategy for shaping radiation fields using a multileaf collimator. Med Phys 2000;27:972-7.|
|6||Fiveash JB, Murshed H, Duan J, Hyatt M, Caranto J, Bonner JA, et al. Effect of multileaf collimator leaf width on physical dose distributions in the treatment of CNS and head and neck neoplasms with intensity modulated radiation therapy. Med Phys 2002;29:1116-9.|
|7||Haryanto F, Fippel M, Bakai A, Nüsslin F. Study on the tongue and groove effect of the elekta multileaf collimator using Monte Carlo simulation and film dosimetry. Strahlenther Onkol 2004;180:57-61.|
|8||Singh IR, Ravindran BP, Ayyangar KM. Design and development of motorized multileaf collimator for telecobalt unit. Technol Cancer Res Treat 2006;5:597-606. |
|9||Cheng CW, Wong JR, Ndlovu AM, Das IJ, Schiff P, Uematsu M. Dosimetric evaluation and clinical application of virtual mini-multileaf collimator. Am J Clin Oncol 2003;26:e37-44.|
|10||Bayouth JE, Morrill SM. MLC dosimetric characteristics for small field and IMRT application. Med Phys 2003;30:2545-52.|
|11||Mardirossian G, Urie M, Fitzgerald TJ. Commissioning of mini-multi-leaf-collimator (MMLC) for stereotactic radiosurgery and radiotherapy. J X-ray Sci Technol 2003;11:21-31.|
|12||Das IJ, Kassaee A, Mitra RK. Dosimetric implication of multileaf collimator leaves for abutting beam blocking and intensity modulation. Engg Med Biol Soc 2000;3:2202-4.|
|13||Glavin JM Smith AR, Lally B, Characterization of a multi-leaf collimator system. Int J Radiat Oncol Biol Physics 1993;25:181-92.|
|14||Huq MS, Yu Y, Chen ZP, Suntharalingam N. Dosimetric characteristics of a commercial multileaf collimator. Med Phys 2002;22:241-7|