Journal of Medical Physics
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Year : 2001  |  Volume : 26  |  Issue : 2  |  Page : 66-70

Estimation Of Effective Half-Life In Patients With Graves Disease



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G S Pant


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Measurement of effective half-life in individual patients provides accurate means for estimating radiation dose to thyroid gland. However, measurement of this parameter requires a number of visits of patient to the hospital. We suggest a method, which requires less number of visits to the hospital without losing the accuracy. We calculated effective half-life (EHL) in 51 cases by two independent methods. The first one used multiple data points (neck counts) for estimation of EHL, whereas in second, only two data points were obtained, namely, at 24 hr, and 48 hr, 24 hr and 72 hr, 24 hr and 96 hr, 24 hr and 120 hr, respectively. The effective half-lives thus determined from two sets of data points were compared with that obtained from multiple data points. The multiple data points correspond to neck counts at 24 hr, 48 hr, 72 hr, 96 hr, and 120 hr. All these observed values were subjected to statistical analysis to check the agreement between two methods. Measurement of neck counts at 24 hr and at either 96 or 120 hr provides a convenient method for determining EHL in individual patients for the purpose of dosimetry.


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