Journal of Medical Physics
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Year : 1996  |  Volume : 21  |  Issue : 4  |  Page : 208-211

Effect Of Misonidazole And Hyperthermia On Radiation-Induced Bone Marrow Damage In Mice : Analysis By CFU-S Assay



Correspondence Address:
K.S Bisht


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The effect of misonidazole (MLSO, 500 mg / kg b.wt.), hyperthermia (HT. 42'C for 30 min) and their combination with or without irradiation (1 .O, 3.0 or 5.0 Gy of gamma rays) was studied on the bone marrow toxicity by the spleen colony (CFU-S) assay. MISO or HT alone did not have any effect, while whole body irradiation produced a significant reduction in the number of CFU-S compared to sham-treated mice. Combination of MIS0 with radiation did not show any significant reduction in the number of CFU-S from that of the irradiated controls. However, post-irradiation HT decreased CFU-S count significantly from the radiation alone treated group. The combination of all the three agents, MISO+ radiation+ HT, produced a further decrease in the stem cell survival from irradiated controls; this effect was sub-additive. Thus, our results indicate that though MISO itself may not have any noticeable radiosensitizing effect on mouse bone marrow stem cells, a sequential administration of MISO, radiation and HT, can enhance the radiation-induced stem cell mortality.


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