Journal of Medical Physics
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Year : 1996  |  Volume : 21  |  Issue : 1  |  Page : 35-39

Evaluation Of a1/a2 Of The Modified Linear Quadratic Model To radiation Isoeffect Data



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T S Keshwar


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The use of modified linear quadratic model in radiotherapeutic practice is extended for fractionated treatment regimes using the formula Em = N[a1d + a2d2 (TI N) -k]. This equation requires data on two important parameters viz. a1 / a2 & k, the values of which vary from tissue to tissue. To estimate a1 / a2, two methods are applied to radiation isoeffect data for spleen and kidney. The parameter k has been estimated from repair half life and cell doubling time of the tissue.


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