Journal of Medical Physics
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Year : 1992  |  Volume : 17  |  Issue : 2  |  Page : 10-12

Extrapolated Response Dose (ERD) AS A Potential Guide In The Management Of Carcinoma Of Uterine Cervix



Correspondence Address:
Sanjay S Supe


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A retrospective analysis of 291 patients with cancer of the uterine cervix treated with a combination of external and intracavitary radiotherapy was carried out. Patients were treated with external radiotherapy dose of 45 Gy in 20 fractions, 5 fractions per week or 42 Gy in 14 fractions, 3 fractions per week. For brachytherapy the total dose was 24 to 32 Gy at a dose rate of'1. 4 to 2.2 gy per hour. Treatment results in terms of response, survival, recurrence and complication were correlated with total Extrapolated Response Dose (ERD) values for point A (ERDTA) and for rectum (ERDT,). ERDTA values did not correlate with response, recurrence and survival rates (p value >0.05). ERDTA values correlated well with rectal complication rate (p value >0.025). Lack of correlation was observed between ERDT, with rectal complication rate (p value >0.1). In order to limit Grade II and Ill rectal complications to acceptable level, in combined external and intracavitary treatments, ERDTA value of less than 93 is suggested.


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