Journal of Medical Physics
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Year : 1990  |  Volume : 15  |  Issue : 2  |  Page : 144-148

Effect Of In Utero Exposure To Diagnostic X-Rays On The Postnatal Development Of Mouse



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Prakesh.M Hande


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Pregnant Swiss mice were exposed to single dose (- 9 mGy) of diagnostic X-rays on day 3.5 (preimplantation period), 6.5 (early organogenesis period) or 11.5 (late organogenesis period) of gestation. The experiment was conducted in 2 sets, (1) with two feeds of normal diet with milk protein (20%), (2) one feed with milk protein and second feed with high protein (38%) fish meal. The offspring was observed for any radiation induced changes in litter size at birth, sex ratio at 4 weeks of age and postnatal mortality, body weight and body length upto 6 weeks of age. Irradiation at the early organogenesis produced an increase in the postnatal death. A significant reduction in postnatal body weight and length was observed in the groups exposed at the early and late organogenesis periods but recovery was evident in the former by 6th week after birth. There was no noticeable influence of diet on the pattern of radiation effects though a high protein diet helped in faster recovery. The results indicate that even a single exposure to about 1 cGy of low energy X-rays can be harmful to the growing embryos and the extent of damage and recovery depends on the stage of development at the time of irradiation


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